Histology transformation-mediated pathological atypism in small-cell lung cancer within the presence of chemotherapy: A case report

Figure 1 Clinical history of the histological transformation from small-cell lung cancer to adenocarcinoma in this patient. A-C: Computed tomography changes of the right lesion in different months with the indicted chemotherapy. D-F: Hematoxylin-eosin staining of bronchoscopy needle aspiration biopsy shows different characteristics and histopathology in corresponding weeks. Magnifications are × 10 (left) and × 40 (right) with 100 μm and 50 μm scale bars.

Figure 2 Immunohistochemical staining of three biopsies. Several typical biomarkers of small-cell lung cancer were examined repeatedly at different stages. Synaptophysin, chromogranin A, CD56 and TTF1 indicate histological transformation. Magnifications are × 40; The scale bar is 50 μm.