Role of circular RNAs in gastrointestinal tumors and drug resistance

Figure 1 The milestones in circRNA research from its discovery in 1976 to present. circRNA: Circular RNA.

Figure 2  Four mechanisms of circular RNA formation including exonic circular RNA, intronic circular RNA, exon-intron circular RNA, intergenic circular RNA.

Figure 3  Circular RNAs have a regulatory effect on gastrointestinal tumors via signaling molecules, and have been shown to influence drug resistance in gastric, liver, intestinal, esophageal, and pancreatic cancer.