Dynamic changes in the radiologic manifestation of a recurrent checkpoint inhibitor related pneumonitis in a non-small cell lung cancer patient: A case report

Figure 1 Computed tomography scan images of the patient during checkpoint inhibitor-related pneumonitis presentation and follow-up. A-C: The first episode of checkpoint inhibitor-related pneumonitis (CIP) after 10 cycles of durvalumab; D-F: Chest computed tomography showed that the changes of the former CIP in the left upper lobe disappeared after 12 cycles of durvalumab; G-I: The second episode of CIP after 12 cycles of durvalumab; J-L: A significant improvement in the CIP at 1 wk after starting methylprednisolone; M-O: The third episode of CIP at completion of methylprednisolone tapering; P-R: Resolution of CIP at 5 mon after completion of methylprednisolone tapering.

Figure 2  A three-dimensional reconstruction of the pneumonitis areas for three episodes. The red, blue, and yellow areas show the first, second, and third episodes of checkpoint inhibitor-related pneumonitis, respectively, taking the pneumonitis areas all together makes nearly a whole lung.