False positive anti-hepatitis A virus immunoglobulin M in autoimmune hepatitis/primary biliary cholangitis overlap syndrome: A case report

Figure 1 Time course of liver function tests and anti-hepatitis A virus immunoglobulin M, autoantibodies, immunoglobulin levels. Total bilirubin: Upper limit of normal (ULN) < 28 μmol/L, aspartate aminotransferase ULN < 40 IU/L, alanine aminotransferase ULN < 45 IU/L, γ-glutamyl transferase ULN < 50 IU/L, alkaline phosphatase ULN < 105 IU/L. ALP: Alkaline phosphatase; ALT: Alanine aminotransferase; ANA: Antinuclear antibody; ASMA: Anti-smooth muscle antibodies; AST: Aspartate aminotransferase; GGT: γ-glutamyl transferase; HAV: Hepatitis A virus; IgG: Immunoglobulin G; IgM: Immunoglobulin M; LKM 1: Anti-liver kidney microsome type 1.

Figure 2 Hematoxylin-eosin staining. A: Liver biopsy tissue shows chronic hepatitis with moderate interface hepatitis accompanied by plasma cell infiltration (hematoxylin-eosin staining; magnification: × 200); B: Image of the box shown in A at 2 × magnification. Showing plasma cell infiltration (white arrow) and bile duct lesions (black arrow).