Neoadjuvant chemotherapy for patients with resectable colorectal cancer liver metastases: A systematic review and meta-analysis

Figure 1 Study identification and selection flow.

Figure 2 Quality assessment of 1 randomized controlled trial. A: Risk of bias graph; B: Risk of bias summary.

Figure 3 Result of 5-year overall survival and disease-free survival. A: 5-year overall survival for all patients and two groups; B: 5-year disease-free survival for all patients and two groups.

Figure 4 Duration of operation for all patients and by study region subgroups.

Figure 5 Number of liver metastases for all patients and by study region subgroups.

Figure 6 Lymph node metastasis for all patients and two groups.

Figure 7 Length of hospital stay and by study region subgroups.

Figure 8 Size of the largest metastasis for all patients and by study region subgroups.

Figure 9 Blood loss during surgery for all patients and by study region subgroups.

Figure 10  Synchronous metastases for all and by study region subgroups.

Figure 11  Major liver resection for all patients and two groups.

Figure 12  R0 liver resections for all patients and two groups.

Figure 13  Blood transfusions for all patients and two groups.

Figure 14  Perioperative complications for all patients and by study region.

Figure 15  Bile leakage for all patients and two groups.

Figure 16  Surgical site infections for all patients and two groups.

Figure 17  Liver failure for all patients and two groups.

Figure 18  Funnel plot for potential publication bias of overall survival.