Case Report
Copyright ©The Author(s) 2021.
World J Clin Cases. Jul 26, 2021; 9(21): 6102-6109
Published online Jul 26, 2021. doi: 10.12998/wjcc.v9.i21.6102
Figure 1
Figure 1 Pathological characteristics. A: Gross appearance of the tumor; B: Microscopic appearance of the tumor with necrosis; C: Microscopic appearance of the tumor with solid pattern and lymphatic stroma; D: The tumor cells were positive for cytokeratin AE1/AE3 by immunohistochemical staining; E: High expression of PDL1 (22C3) CPS>1; F: Epstein–Barr virus encoded small RNA was negative (figures at 100-200 × magnification).
Figure 2
Figure 2 Expression of mismatch repair-related proteins by immunohistochemical staining. The tumor cells were completely negative for all four proteins. A: MLH1; B: PMS2; C: MSH2; D: MSH6 (all images at 200 × magnification).
Figure 3
Figure 3 Results of next-generation sequencing. The mutation of MSH2 and amplification of PIK3CA were observed.