Stevens-Johnson syndrome and concurrent hand foot syndrome during treatment with capecitabine: A case report

Figure 1 The patient’s gross appearance before treatment. A: A physical examination showed erythema, desquamation, and erosions on her right palm; B: Her both soles showed severe erythema, desquamation and erosions; C: Erythema and erosions were also present in her buttock; D: Vesicles and erosions were observed on the trunk with Nikolsky’s sign.

Figure 2 The histopathological findings revealed extensive eosinophilic epidermal necrosis, focal subepidermal blisters, and separation of the epidermis from dermis. A: hematoxylin and eosin, × 40; B: hematoxylin and eosin, × 200.

Figure 3 The patient’s gross appearance after treatment. A: Completely re-epithelialization was observed on the palms after 3 wk of Vaseline gauze dressing; B: Completely re-epithelialization was observed on the soles after 3 wk of Vaseline gauze dressing.