Clinical significance and prognostic value of tumor necrosis factor-α and dickkopf related protein-1 in ankylosing spondylitis

Figure 1 Difference in Dickkopf-related protein-1 expression in the two groups. A: Difference in dickkopf-related protein-1 (DKK-1) expression between the control group and the research group before treatment; B: Difference in DKK-1 expression before and after treatment in the research group; C: Correlation between DKK-1 and C-reactive protein; D: Correlation between DKK-1 and Immunoglobulin G; E: Correlation between DKK-1 and Immunoglobulin A; F: Correlation between DKK-1 and Immunoglobulin M; G: Correlation between DKK-1 and HLA-B27; H: Correlation between DKK-1 and erythrocyte sedimentation rate; I: Correlation between DKK-1 and the Bath Ankylosing Spondylitis Disease Activity Index; J: Correlation between DKK-1 and the Bath Ankylosing Spondylitis Metrology Index. ^aP < 0.05.

Figure 2 Difference in tumor necrosis factor-α expression in the two groups. A: Difference in tumor necrosis factor-αexpression between the control group and the research group before treatment; B: Difference in tumor necrosis factor-α expression before and after treatment in the research group. ^aP < 0.05. TNF-α: Tumor necrosis factor-α.

Figure 3 Diagnostic value of dickkopf-related protein-1 and tumor necrosis factor-α in ankylosing spondylitis. The area under the curve, cutoff value, sensitivity and specificity of dickkopf-related protein-1 for diagnosing ankylosing spondylitis were 0.752, 87.02 pg/mL, 78.76% and 66.00% respectively, and those of tumor necrosis factor-α were 0.904, 18.79 ng/L, 79.65% and 95.00%. The area under the curve, sensitivity and specificity of combined diagnosis were 0.934, 82.30% and 97.00% respectively. TNF-α: Tumor necrosis factor-α; DKK: dickkopf-related protein-1.

Figure 4 Predictive value of dickkopf-related protein-1 and tumor necrosis factor-α in the curative effect in ankylosing spondylitis. The area under the curve, cutoff value, sensitivity and specificity of dickkopf-related protein-1 for predicting the curative effect before treatment were 0.825, 68.42 pg/mL, 73.68% and 80.00% respectively, and those of tumor necrosis factor-α were 0.863, 32.79 ng/L, 92.11% and 77.33%, respectively. TNF-α: Tumor necrosis factor-α; DKK: Dickkopf-related protein-1.

Figure 5 Correlation between dickkopf-related protein-1, tumor necrosis factor-α and the curative effect in ankylosing spondylitis. A: Correlation between dickkopf-related protein-1 and curative effect in ankylosing spondylitis; B: Correlation between tumor necrosis factor-α and curative effect in ankylosing spondylitis. TNF-α: Tumor necrosis factor-α; DKK: Dickkopf-related protein-1.