Virus load and virus shedding of SARS-CoV-2 and their impact on patient outcomes

Figure 1 Patient flowchart. SARS-Cov-2: Severe acute respiratory syndrome coronavirus 2.

Figure 2 Box plot showing the cycle threshold value differences at the day of hospital admission. A: Duration of intensive care unit stay (< 7 vs ≥ 7 d) (one-sided t test, P = 0.02); B: Vital status (death or not) (one-sided t test, P < 0.0001); C: Procedures (mechanical ventilation needed or not) (one-sided t test, P = 0.009); D: Results at admission (interleukin 6) (one-sided t test, P = 0.05). Ct: Cycle threshold; MV: Mechanic ventilation; IL-6; Interleukin 6; ICU: Intensive care unit.

Figure 3 Factors associated with the duration of viral shedding. A: Changes in cycle threshold values during hospitalization using generalized additive models (F: 46.54, P < 0.0001, adjusted for sex and age); B: From symptom onset to hospital admission (χ²: 85.31, P < 0.0001); C: Cumulative proportions of patients with symptom onset to admission < 7 d, 7-14 d, and > 14 d (χ² = 76.58, P < 0.001); D: Cumulative proportions of patients with PaO₂/FiO₂ < 100, 100-200, > 200 (χ² = 53.74, P < 0.0001) at admission; E: Cumulative proportion of patients with chloroquine or without (P < 0.0001). Ct: Cycle threshold; SARS-Cov-2: Severe acute respiratory syndrome coronavirus 2.