Rituximab-induced IgG hypogammaglobulinemia in children with nephrotic syndrome and normal pre-treatment IgG values

Figure 1 Trend of the IgG values among patients presenting IgG hypogammaglobulinemia and survival from IgG hypogammaglobulinemia. A: Trend of the IgG values among patients presenting with IgG hypogammaglobulinemia. Eight patients (dark coloured) developed IgG hypogammaglobulinemia after the “starting doses” (7 out of 8 patients showed IgG hypogammaglobulinemia at the scheduled follow-up 3 mo after the RTX “starting doses”, and one patients developed IgG hypogammaglobulinemia 24 mo after the RTX infusion), one (green coloured) patient after the third dose (this patient showed IgG hypogammaglobulinemia 3 mo after the third dose), one (blue coloured) after the fourth (this patient showed IgG hypogammaglobulinemia 3 mo after the fourth dose), and one (red coloured) after the fifth dose (this patient showed IgG hypogammaglobulinemia 13 mo after the fifth dose); B: Survival from IgG hypogammaglobulinemia. The cumulative proportion of patients free of IgG hypogammaglobulinemia was 57.8% after the first dose of RTX, 51.5% after the third dose, 44.1% after the fourth dose, and 35.5% after the fifth dose. The time between the RTX infusion and IgG hypogammaglobulinemia onset is specified in the legend of Figure 1A. RTX: Rituximab; IgG: Immunoglobulin G.