Adjuvant chemotherapy with S-1 plus oxaliplatin improves survival of patients with gastric cancer after D2 gastrectomy: A multicenter propensity score-matched study

Figure 1 Flowchart of the study population. GC: Gastric cancer; SOX: S-1 plus oxaliplatin.¹High-risk features include poorly differentiated or higher grade cancer,lymphovascular invasion, neural invasion, or ＜50 years of age.

Figure 2 Kaplan-Meier curves for disease-free survival (A) and overall survival (B) between matched patients in the surgery alone group and adjuvant S-1 plus oxaliplatin group. SOX: S-1 plus oxaliplatin; HR: Hazard ratio.

Figure 3 Kaplan-Meier curves for disease-free survival and overall survival of subgroups between matched patients in the surgery alone group and adjuvant S-1 plus oxaliplatin group. A: Disease-free survival (DFS) in matched patients with stage III; B: Overall survival (OS) in matched patients with stage III; C: DFS in matched patients who ≤ 60 years old; D: OS in matched patients who ≤ 60 years old; E: DFS in matched patients who > 60 years old; F: OS in matched patients who > 60 years old. SOX: S-1 plus oxaliplatin; HR: Hazard ratio.

Figure 4 Kaplan-Meier curves for disease-free survival (A) and overall survival (B) between matched patients in the adjuvant S-1 plus oxaliplatin group and adjuvant capecitabine plus oxaliplatin group. SOX: S-1 plus oxaliplatin; XELOX: Capecitabine plus oxaliplatin; HR: Hazard ratio.