Mystery behind labial and oral melanotic macules: Clinical, dermoscopic and pathological aspects of Laugier-Hunziker syndrome

Figure 1 Lenticular melanotic macule on the lower lip of a Laugier-Hunziker syndrome patient.

Figure 2 Dermoscopic findings of the Laugier-Hunziker syndrome patient. Granular (closed arrowhead) and linear (open arrowhead) patterns coexist in the labial pigmented lesion.

Figure 3 Pathological findings of the Laugier-Hunziker syndrome patient. Accumulated melanin in the basal layer (closed arrowhead) and slightly increased melanophages in the lamina propria (open arrowhead) (HE stain × 200).

Figure 4 The differentiation and relationship between several main syndromes or systemic disorders characterized by diffuse mucocutaneous pigmentation. Red circle: Malignancy risk; Green circle: Inheritance tendency.