Primary extragastrointestinal stromal tumor arising in the vaginal wall: Significant clinicopathological characteristics of a rare aggressive soft tissue neoplasm

Figure 1 Gross findings of the specimen. A: Elliptical gray-white and grey-red soft tissue mass with fibrous capsule; B: Medium texture with multiple hemorrhage and necrosis on the cut surface.

Figure 2 Histological findings of the tumor. A: The tumor was composed of cellular spindle cells with a large area of necrosis. Hematoxylin and eosin (× 200); B: Active mitosis of tumor cells. Hematoxylin and eosin (× 400). Immunohistochemical findings of the tumors; C: Diffusely and strongly DOG1 positive in the tumor cells (× 400); D: Diffusely and strongly CD117 (c-kit pro-oncogene product) positive in the tumor cells (× 400).

Figure 3 Computer analysis of a part of exon 11 of the c-kit gene in the tumor. Deletion of codons 557-558 was noted. Asterisks showed the deletion.