Published online Apr 16, 2016. doi: 10.12998/wjcc.v4.i4.118
Peer-review started: November 6, 2015
First decision: December 23, 2015
Revised: December 30, 2015
Accepted: February 14, 2016
Article in press: February 16, 2016
Published online: April 16, 2016
Gastrointestinal (GI) stromal tumor is the most common mesenchymal neoplasm of the GI tract but also occurs with a lower frequency in extragastrointestinal regions and is called extragastrointestinal stromal tumor (EGIST). We report an unusual case of EGIST presenting as a vaginal mass. A 41-year-old woman presented with a gradually enlarging vaginal mass for the last 2 years. Physical examination revealed an elliptical, non-tender mass about 7.5 cm × 7 cm in size in the posterior vaginal wall and was resected completely. Under histological examination, the tumor showed a spindle cell type with coagulation necrosis, hemorrhage and high mitotic count. Immunohistochemical analysis revealed tumor cells were positive for DOG1, CD117, CD34 and p53 protein. Ki-67 labeling was 8%. Genetic analysis showed a deletion of exon 11 of the c-kit gene at codons 557-558. EGISTs should be kept in mind in the differential diagnosis in patients presenting with solid mass of the vaginal wall.
Core tip: Gastrointestinal (GI) stromal tumor is the most common mesenchymal neoplasm of the GI tract but also occurs with a lower frequency in extragastrointestinal regions and is called extragastrointestinal stromal tumor (EGIST). We report an unusual case of EGIST presenting as a vaginal mass and describe its clinicopathological, immunohistochemical and genetic features. Our data shows that this case was a primary malignant EGIST in the vaginal wall but few cases of primary vaginal EGIST have been reported to date. EGISTs should be kept in mind in the differential diagnosis of patients presenting with a solid mass of the vaginal wall.