Urothelial carcinoma arising in orthotopic ileal neobladder reconstruction: A case report

Figure 1 Cystoscopic and macroscopic appearance. A: Cystoscopy reveals a papillary tumor with white exudate adherent in the left lateral side of the ileal neobladder, which was located distal to the anastomosis (yellow arrowhead); B: Macroscopic appearance of the resected specimen showing an irregular papillary surface with exophytic growth pattern in the ileal neobladder measuring 20 mm × 15 mm. The tumor is located in the left wall of the ileal neobladder (yellow arrow); C: The cut surface of the tumor is grey to white in color.

Figure 2 Microscopic and immunohistochemical findings. A: The loupe section shows that the papillary arrangement of urothelium with a fibrovascular core. [hematoxylin and eosin (HE) stain, magnification 10 ×]; B: Significant architectural and nuclear atypia, including loss of polarity (HE stain, magnification 200 ×); C: Immunohistochemical staining for GATA binding protein 3 reveals positivity in urothelial carcinoma (immunostaining, magnification 200 ×).