Murakami M, Noguchi H, Matsushita R, Tatarano S, Kirishima M, Tasaki T, Kitazono I, Higashi M, Enokida H, Tanimoto A. Urothelial carcinoma arising in orthotopic ileal neobladder reconstruction: A case report. World J Clin Cases 2025; 13(26): 104876 [DOI: 10.12998/wjcc.v13.i26.104876]
Corresponding Author of This Article
Akihide Tanimoto, MD, PhD, Professor, Department of Pathology, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan. akit09@m3.kufm.kagoshima-u.ac.jp
Research Domain of This Article
Pathology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Miki Murakami, Hirotsugu Noguchi, Mari Kirishima, Takashi Tasaki, Ikumi Kitazono, Michiyo Higashi, Akihide Tanimoto, Department of Pathology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8544, Japan
Ryosuke Matsushita, Shuichi Tatarano, Hideki Enokida, Department of Urology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8544, Japan
Co-first authors: Miki Murakami and Hirotsugu Noguchi.
Author contributions: Murakami M and Noguchi H performed the pathological analysis and wrote the initial draft of the manuscript; Matsushita R, Shuichi Tatarano, and Enokida H were the patient’s surgeons, reviewed the literature, and contributed to manuscript drafting; Kirishima M, Tasaki T, Kitazono I, and Higashi M performed the pathological examination, reviewed the literature, and contributed to manuscript drafting; Tanimoto A was responsible for revising the manuscript for important intellectual content; all authors have read and approved the final manuscript.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that there is no potential conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Akihide Tanimoto, MD, PhD, Professor, Department of Pathology, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan. akit09@m3.kufm.kagoshima-u.ac.jp
Received: January 5, 2025 Revised: April 18, 2025 Accepted: June 4, 2025 Published online: September 16, 2025 Processing time: 199 Days and 17.5 Hours
Abstract
BACKGROUND
An ileal neobladder is a standardized form of urinary diversion that provides acceptable outcomes in terms of long-term quality of life. Urothelial carcinomas (UCs) arising in the ileal neobladder are extremely rare, and few reports on this have been published in the English language.
CASE SUMMARY
We report a case of UC that developed in the ileal neobladder of a 63-year-old man. The patient was diagnosed with UC in situ and underwent radical cystoprostatectomy and ileal neobladder creation. Ten years after the surgery and neoadjuvant chemotherapy, an UC developed in the ileal neobladder.
CONCLUSION
Ileal neobladder urothelial carcinoma can originate from the implanted urothelium and the intestinal mucosa can migrate intraluminally.
Core Tip: The simultaneous or metachronous occurrence of multifocal tumors in the urinary tract is characteristic of urothelial carcinoma (UC), and many patients experience recurrence post-surgery. However, recurrence of UC in ileal neobladders is extremely rare. Most cases of UC in the ileal neobladder are initially diagnosed as muscle-invasive bladder cancers. In this case, the pathological stage of the resected bladder after neoadjuvant chemotherapy was UC in situ. Patients who have undergone ileal neobladder surgery should be carefully followed up for a long period because the exfoliated tumor cells could “seed and implant” in the bladder and non-urothelial epithelium.
