CXCR4 expression and clinicopathological features of endometrial endometrioid carcinoma with the microcystic, elongated, and fragmented pattern

Figure 1 Integrated analysis of histopathological findings and Immunohistochemistry results. A-C: Representative image of endometrioid endometrial carcinoma (EEC) with microcystic, elongated, and fragmented (MELF) (× 200); D: Representative image of EEC with MELF and cervical stromal involvement (× 40); E: Lymph node metastasis (× 200); F: Image showing strong positive CXC chemokine receptor 4 (CXCR4) expression in MELF area (× 200); G: Image showing weak positive CXCR4 expression in MELF area (× 200); H: Image showing weak positive CXCR4 expression in EEC main area (× 200); I: Image showing positive estrogen receptor expression in EEC, strong positive in the main area, weakly positive in MELF area (in the lower picture) (× 100).

Figure 2 Survival estimate between microcystic, elongated, and fragmented group and non- microcystic, elongated, and fragmented group. There was significant difference in progression-free survival between microcystic, elongated, and fragmented (MELF) group and non-MELF group by Kaplan-Meier analysis (P < 0.05). MELF: Microcystic, elongated, and fragmented.