Retrospective Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jul 26, 2025; 13(21): 103841
Published online Jul 26, 2025. doi: 10.12998/wjcc.v13.i21.103841
CXCR4 expression and clinicopathological features of endometrial endometrioid carcinoma with the microcystic, elongated, and fragmented pattern
Ji-Xian Wang, Dan-Hua Shen, Xiao-Bo Zhang
Ji-Xian Wang, Dan-Hua Shen, Xiao-Bo Zhang, Department of Pathology, Peking University People’s Hospital, Beijing 100044, China
Author contributions: Shen DH and Zhang XB designed the research study; Wang JX, Shen DH, Zhang XB performed the research; Wang JX and Zhang XB wrote the manuscript; All authors have read and approved the final manuscript.
Institutional review board statement: This study was approved by the Peking University People's Hospital's ethics committee (approval 2024PHB187-001). We certify that the study was performed by the 1964 declaration of Helsinki and later amendments.
Informed consent statement: Written informed consent was obtained from all the participants before the enrollment of this study.
Conflict-of-interest statement: All authors declare that they have no conflict of interest to disclose.
Data sharing statement: The authors will supply the relevant data in response to reasonable requests.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiao-Bo Zhang, Department of Pathology, Peking University People’s Hospital, No. 11 Xizhimen South Street, Beijing 100044, China. zhangxiaobo0326@163.com
Received: December 13, 2024
Revised: March 19, 2025
Accepted: March 20, 2025
Published online: July 26, 2025
Processing time: 135 Days and 16.8 Hours
Core Tip

Core Tip: Endometrioid endometrial carcinoma (EEC) with the microcystic, elongated, and fragmented (MELF) invasion is a special invasive pattern, and its risk of lymphovascular space invasion and lymph node metastasis is significantly higher than that of the non-MELF group. The presence of MELF infiltration in EEC is associated with a higher expression of CXC chemokine receptor 4, which may play a role in the progression of the disease.