Blastic plasmacytoid dendritic cell neoplasm in Jinhua, China: Two case reports

Figure 1 Skin condition of case 1. Scattered dark purplish red nodules and plaques throughout the body. A: Scattered rashes and patches of varying sizes can be seen on the patient's neck, chest and back, and limbs; B: The right upper arm patch is dark red, almost round, and the border is clear; C: Dark red tubercle on the left elbow, 7.5 cm in diameter, without rupture.

Figure 2 Microscopic pathological images of HE in two patients. A: Case 1 tumor cells do not invade the epidermis, the cell-free zone between the epidermis (HE staining, 40 times), EnVision two-step method, Bar = 200 μm; B: Case 2 tumor cells do not invade the epidermis, interepidermal cell-free zone (HE staining, 40 times), EnVision two-step method, Bar = 200 μm; C: Case1 tumor cells were single, medium size, nuclear round or oval, chromatin fine (HE, 200 ×), EnVision two-step method, Bar = 50 μm; D: Case 2 tumor cells single, medium size, round or oval nuclei, fine chromatin (HE, 200 ×), EnVision two-step method, Bar = 50 μm; E: Case1 case image showing small nucleolus and nuclear fission (HE, 400 ×), EnVision two-step method, Bar = 20 μm; F: Case 2 case images showing small nucleolus and nuclear fission (HE, 400 ×), EnVision two-step method, Bar = 20 μm.

Figure 3 Immunophenotypes of two patients. A: Case 1 tumor cells are diffuse CD4 positive (IHC, 200 ×), EnVision two-step method; B: Case 1 tumor cells are diffusively CD56 positive (IHC, 200 ×), EnVision two-step method; C: Case 1 tumor cells are diffusively CD43 positive (IHC, 200 ×), EnVision two-step method; D: Case 1 tumor cells are diffusively CD123 positive (IHC, 200 ×), EnVision two-step method; E: Case 2 tumor cells are diffuse CD4 positive (IHC, 200 ×), EnVision two-step method; F: Case 2 tumor cells are diffusively CD56 positive (IHC, 200 ×), EnVision two-step method; G: Case 2 tumor cells are diffusively CD43 positive (IHC, 200 ×), EnVision two-step method; H: Case 2 tumor cells are diffusively CD123 positive (IHC, 200 ×), EnVision two-step method. All bars are 50 μm.