Case Report
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Aug 6, 2024; 12(22): 5263-5270
Published online Aug 6, 2024. doi: 10.12998/wjcc.v12.i22.5263
Blastic plasmacytoid dendritic cell neoplasm in Jinhua, China: Two case reports
Jia-Wei Cai, Meng-Yao Li, Wei-Hao Wang, Hong-Qi Shi, Yi-Hui Yang, Jia-Jun Chen
Jia-Wei Cai, Hong-Qi Shi, Yi-Hui Yang, Department of Pathology, Jinhua Hospital, Jinhua 321000, Zhejiang Province, China
Meng-Yao Li, Department of Pathology, Shaoxing People’s Hospital, Shaoxing 312000, Zhejiang Province, China
Wei-Hao Wang, Jia-Jun Chen, Department of Urology, Shaoxing People's Hospital, Shaoxing 312000, Zhejiang Province, China
Co-first authors: Jia-Wei Cai and Wei-Hao Wang.
Author contributions: Cai JW conception and design of study, drafting of manuscript and critical revision; Li MY conception and design of study, approval of final version of manuscript; Wang WH data analysis and interpretation; Shi HQ acquisition of data (laboratory or clinical); Yang YH and Chen JJ data analysis and Interpretation. All authors have read and approved the final manuscript. Cai JW and Wang WH contributed equally to this work as co-first authors.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jia-Jun Chen, Doctor, Attending Doctor, Department of Urology, Shaoxing People's Hospital, No. 568 Zhongxing North Road, Shaoxing 312000, Zhejiang Province, China. 17858515899@163.com
Received: April 29, 2024
Revised: May 31, 2024
Accepted: June 20, 2024
Published online: August 6, 2024
Processing time: 64 Days and 0.1 Hours
Core Tip

Core Tip: Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a highly malignant tumor of the hematopoietic and lymphoid tissue, which is extremely rare. BPDCN is highly aggressive and often involves the skin, lymph nodes and bone marrow, with rapid clinical progression and a poor prognosis. In this paper, we retrospectively analyzed 2 cases of BPDCN and reviewed their pathological features, immunophenotype, differential diagnosis, treatment and prognosis, with the aim of improving pathologists’understanding of this entity.