Goblet cell carcinoid of the appendix: Six case reports

Figure 1 Abdominal computed tomography of the appendix in 6 patients. Arrowheads indicate the appendix for each case. A: Case 1; B: Case 2; C: Case 3; D: Case 4; E: Case 5; F: Case 6.

Figure 2 Findings on colonoscopy. A and B: In Case 1, colonoscopy shows edematous mucosa of the cecal wall (A), but no neoplastic changes are apparent at the cecum or appendiceal orifice (B); C: In Case 4, colonoscopy before additional ileocecal resection shows no neoplastic changes at the cecum or appendiceal orifice.

Figure 3 Representative pathological examination of goblet cell carcinoid in Case 1. A: Hematoxylin and eosin (HE) staining shows a mixed pattern comprising large goblet cells mimicking signet-ring cells containing mucus; B: Periodic acid-Schiff (PAS) staining for mucin is positive; C and D: Immunohistochemical staining is positive for chromogranin A (CgA) (C) and synaptophysin (D).

Figure 4 Resected specimen and tumor mapping. A-C: Although no neoplastic changes are seen at the cecal surface or appendiceal orifice in Case 1 (A) or Case 4 (C), tumor cells have invaded widely into the cecum in Case 1 (B); D: Residual tumor cells are seen microscopically at the cecum around the appendiceal orifice in Case 4. Red lines show the existence of tumor cells.