Vascular endothelium, a promising target for effectively treating fulminant diquat intoxication?

Figure 1 Observation of sublingual microcirculation in patients with fulminant diquat poisoning using side-stream dark field technology. Capillaries constrict intensively and become narrower, leading to a reduction in blood flow velocity and a significant impairment of microcirculation.

Figure 2 Transmission electron microscopy examination of the lungs and kidneys after post-mortem biopsies of patients with fulminant diquat poisoning. A and B: Lung; C: Kidney. Severe congestion and even bleeding are observed, and the endothelial cells exhibit severe vacuolar degeneration (orange arrow).