Synchronous endometrial and ovarian cancer: A case report

Figure 1 Haematoxylin and eosin staining in case I. A: Haematoxylin and eosin (H&E)-stained slide at low power (lens objective × 4) shows closely packed irregular glandular structures; B: H&E-stained slide at medium power (lens objective × 14) shows columnar epithelium with oval, stratified nuclei and visible nucleoli; C: H&E-stained slide at low power (lens objective × 4) shows closely packed irregular glandular structures and focal solid growth; D: H&E-stained slide at medium power (lens objective × 14) shows tumor composed of moderate amount of eosinophilic cytoplasm with slightly polymorphous nuclei and visible nucleoli.

Figure 2 Haematoxylin and eosin staining in case II. A: Haematoxylin and eosin-stained (H&E) slide at low power (lens objective × 4) shows closely packed irregular glandular structures; B: H&E-stained slide at medium power (lens objective × 14) shows tall columnar epithelium with oval, stratified nuclei with visible nucleoli; C: H&E-stained slide at low power (lens objective × 4) shows closely packed irregular glandular structures with focal necrosis; D: H&E-stained slide at medium power (lens objective × 14) shows columnar epithelium with oval, stratified nuclei, and visible nucleoli.

Figure 3 Crosstalk of PI3K/AKT and WNT pathways in synchronous endometrial and ovarian. Both pathways converge at glycogen synthase kinase-3 beta (GSK3β): In PI3K/AKT pathway, activation of PI3K is required for AKT activation and downstream signaling. PTEN acts as deactivator of PI3K pathway. AKT also phosphorylates and inactivates GSK3β. Meanwhile in WNT signaling GSK3β/Axin complex is required for β-catenin phosphorylation and degradation. The numbers indicate TCGA published mutation data form uterine (right side data) and ovarian (left side data) cancers. Figure generated using PathwayMapper tool. GSK3β: Glycogen synthase kinase-3 beta.