Žilovič D, Čiurlienė R, Šidlovska E, Vaicekauskaitė I, Sabaliauskaitė R, Jarmalaitė S. Synchronous endometrial and ovarian cancer: A case report. World J Clin Cases 2023; 11(18): 4341-4349 [PMID: 37449219 DOI: 10.12998/wjcc.v11.i18.4341]
Corresponding Author of This Article
Diana Žilovič, Doctor, Doctor, Researcher, Department of Oncogynecology, National Cancer Institute, 1 Santariskiu Street, Vilnius 08406, Lithuania. dianauljanionok@gmail.com
Research Domain of This Article
Oncology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Diana Žilovič, Rūta Čiurlienė, Department of Oncogynecology, National Cancer Institute, Vilnius 08406, Lithuania
Diana Žilovič, Ieva Vaicekauskaitė, Sonata Jarmalaitė, Institute of Biosciences, Vilnius University, Vilnius 10222, Lithuania
Diana Žilovič, Laboratory of Clinical Oncology, National Cancer Institute, Vilnius 08406, Lithuania
Evelina Šidlovska, National Center of Pathology, Affiliate of Vilnius University Hospital Santaros Klinikos, Vilnius 08406, Lithuania
Ieva Vaicekauskaitė, Rasa Sabaliauskaitė, Sonata Jarmalaitė, Laboratory of Genetic Diagnostic, National Cancer Institute, Vilnius 08406, Lithuania
Author contributions: Žilovič D, Čiurlienė R, and Jarmalaitė S contributed to conceptualization; Žilovič D and Čiurlienė R contributed to sample collection; Vaicekauskaitė I, Vaicekauskaitė I, and Sabaliauskaitė R contributed to sample preparation, and DNA extraction; Žilovič D, Čiurlienė R, and Šidlovska E contributed to clinical data curation; Žilovič D contributed to writing-original draft preparation; Vaicekauskaitė I and Šidlovska E contributed to visualization; Jarmalaitė S contributed to supervision; all authors contributed to formal analysis and writing-review and editing; and all authors have read and agreed to the published version of the manuscript.
Informed consent statement: Informed written consent was obtained from the patients for the publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Diana Žilovič, Doctor, Doctor, Researcher, Department of Oncogynecology, National Cancer Institute, 1 Santariskiu Street, Vilnius 08406, Lithuania. dianauljanionok@gmail.com
Received: February 6, 2023 Peer-review started: February 6, 2023 First decision: April 26, 2023 Revised: May 4, 2023 Accepted: May 22, 2023 Article in press: May 22, 2023 Published online: June 26, 2023 Processing time: 140 Days and 3.1 Hours
Abstract
BACKGROUND
Synchronous endometrial and ovarian cancer (SEOC) is a rare genital tract tumor. Precise diagnosis is crucial for the disease management since prognosis and overall survival differ substantially between metastatic endometrial cancer (EC) or OC. In this review we present 2 cases of women who were diagnosed with SEOC, and discuss the clinical characteristic of SEOC, diagnostic and molecular profiling issues. Next generation sequencing of 10 gene panel was performed on cancerous tissue and uterine lavage samples.
CASE SUMMARY
In our report patients with SEOC had endometroid type histology with early stage and low-grade histology for both EC and OC. They underwent surgical treatment and staging. Next-generation sequencing of 10 gene-panel identified CTNNB1, PIK3CA, and PTEN gene mutations in ovarian tissue in one case, while none of these genes were mutated in other case. Literature review in support to our data suggest a good prognosis for SEOC diagnosed at early stage.
CONCLUSION
Accurate diagnosis of SEOC is essential for disease management and gene mutation analysis can be helpful as a complementary diagnostic and prognostic tool.
Core Tip: Synchronous gynecological tumors are a rare entity. The most common synchronous tumor is synchronous endometrial and ovarian cancer (SEOC). The importance of distinguishing SEOC from either isolated endometrium or ovarian cancer with metastasis is crucial, as it determines management and prognosis. When molecular testing was carried out for SEOC cases, a large proportion was found to be metastatic disease. Testing of vimentin, molecular analyses of gene mutation of CTNNB1, Paired box gene 8, β-catenin expression may be helpful to categorize SEOC in cases where clinical and pathological parameters are inconclusive.
