Kikuchi-Fujimoto disease: A comprehensive review

Figure 1 Histopatholgy of a lymph node in Kikuchi-Fujimoto disease. A: Scanner power view of a lymph node in Kikuchi-Fujimoto disease: The pale foci located in between the benign germinal centers are due to the collection of histiocytes(Stain, H&E; × 4); B: Focal areas of the effaced architecture of the lymph node by necrotic foci. Necrosis and pink debris among histiocytes and lymphocytes are typically seen while well-formed granulomas are absent (Stain, H&E; × 10); C: Seen here are focal areas of necrosis without neutrophils and sheets of histiocytes with pale nuclei with a violaceous hue and pink cytoplasm (Stain, H&E; × 40); D: Histiocytes with round-to-sickle-shaped nuclei and typical pink necrotizing nodules mainly composed of histiocytic debris. Neutrophils or suppurative abscesses, a hallmark of suppurative granulomas, are conspicuously absent (Stain, H&E; × 100).

Figure 2 Immunohistochemical staining of lymph node inKikuchi-Fujimoto disease. A: Kikuchi-Fujimoto disease: CD8 immunostaining of lymph node biopsy showing predominantly CD8+ T (cytotoxic) cells highlighting lymphoid cells and large immunoblasts (× 10); B: Kikuchi-Fujimoto disease: Immunohistochemistry of lymph node biopsy showing CD68+ histiocytes in the necrotic areas (× 10).