Mahajan VK, Sharma V, Sharma N, Rani R. Kikuchi-Fujimoto disease: A comprehensive review. World J Clin Cases 2023; 11(16): 3664-3679 [PMID: 37383134 DOI: 10.12998/wjcc.v11.i16.3664]
Corresponding Author of This Article
Vikram K Mahajan, MD, Professor, Department of Dermatology, Venereology and Leprosy, Dr. Radhakrishnan Government Medical College, Hamirpur 177001, Himachal Pradesh, India. vkm1@rediffmail.com
Research Domain of This Article
Dermatology
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Jun 6, 2023; 11(16): 3664-3679 Published online Jun 6, 2023. doi: 10.12998/wjcc.v11.i16.3664
Kikuchi-Fujimoto disease: A comprehensive review
Vikram K Mahajan, Vikas Sharma, Neeraj Sharma, Ritu Rani
Vikram K Mahajan, Vikas Sharma, Neeraj Sharma, Ritu Rani, Department of Dermatology, Venereology and Leprosy, Dr. Radhakrishnan Government Medical College, Hamirpur 177001, Himachal Pradesh, India
Author contributions: Mahajan VK planned, obtained, compiled, analyzed and interpreted the data, prepared the draft, and critically evaluated the manuscript for important intellectual content; Sharma V, Sharma N, and Rani R helped in planning, compiling, and preparing the draft; all authors were involved in the revision of the manuscript and agreed to the final content.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Vikram K Mahajan, MD, Professor, Department of Dermatology, Venereology and Leprosy, Dr. Radhakrishnan Government Medical College, Hamirpur 177001, Himachal Pradesh, India. vkm1@rediffmail.com
Received: December 27, 2022 Peer-review started: December 27, 2022 First decision: March 24, 2023 Revised: March 29, 2023 Accepted: April 27, 2023 Article in press: April 27, 2023 Published online: June 6, 2023
Core Tip
Core Tip: Kikuchi-Fujimoto disease or Kikuchi disease described originally in young Japanese women is a rare benign cause of fever and lymphadenopathy usually involving cervical lymph nodes. The disease has been reported worldwide in both genders across ethnic and age groups. Histopathologically, histiocytic necrotizing lymphadenitis is characteristic and needs differentiation from more serious conditions such as malignant lymphoma in acute or subacute form. Its long-term prognosis is favorable albeit long-term follow-up is recommended because of a rare but increased risk of developing systemic lupus erythematosus/other autoimmune disorders. Patients with a severe or recurrent disease need treatment with nonsteroidal anti-inflammatory drugs, systemic corticosteroids, and/or other immunomodulators.
