Computed tomography perfusion imaging evaluation of angiogenesis in patients with pancreatic adenocarcinoma

Figure 1 Representative computed tomography perfusion parameters in the pancreas of a healthy volunteer.

Figure 2 Representative computed tomography perfusion parameters of grade II (left) vs grade III (right) pancreatic adenocarcinoma patients. The pancreatic adenocarcinoma patients had a lower density on the maximum-density projection images, as well as lower values of blood flow, blood volume, and permeability, as compared with the adjacent relatively normal pancreatic tissue.

Figure 3 Immunohistochemical indicators in patients with pancreatic adenocarcinoma. CD34-MVD, CD105-MVD, VEGF, and (α-SMA)-MVD in patients with grade III pancreatic adenocarcinoma (right) were compared with CD34-MVD, CD105-MVD, VEGF, and (α-SMA)-MVD in patients with grade I pancreatic adenocarcinoma (left). Magnification × 400.

Figure 4 Correlation between relative blood flow and relative blood volume and angiogenesis rate. A: Correlation between relative blood flow and angiogenesis rate (AR); B: Correlation between relative blood volume and AR.