Congenital dysfibrinogenemia misdiagnosed and inappropriately treated as acute fatty liver in pregnancy: A case report and review of literature

Figure 1 Pedigree. Affected II1 (proband) had congenital dysfibrinogenemia and carried the genetic mutation in the fibrinogen alpha chain gene (p.R350H). I1, I3, II1, and III1 carry the causative pathogenic gene.

Figure 2 Coagulation results. A: The pregnant patient during hospitalization. Fibrinogen dropped below the critical value several times, and fresh frozen plasma or cryoprecipitate was injected immediately; B: The newborn during hospitalization. PT: Prothrombin time; APTT: Activated partial thromboplastin time; TT: Thrombin time; FIB: Fibrinogen.

Figure 3 The process of patient admission, diagnosis, and treatment. ICU: Intensive care unit; FGA: Fibrinogen alpha chain gene.