t(4;11) translocation in hyperdiploid de novo adult acute myeloid leukemia: A case report

Figure 1 Bone marrow examination at diagnosis. A: Bone marrow (BM) smear showed large and irregular cells, with rich and dusty blue cytoplasm and a few azurophilic granules; chromatin was rough and loose, light purple red, and nucleoli were not clear; B: Peroxidase staining was weak positive; C: Flow cytometry showed that 91.87% myeloid cells in BM were malignant clones, expressing CD33⁺, CD9⁺, CD38⁺, CD15⁺, CD64⁺, cMPO⁺, BCL2⁺, HLA-DR^+/-, CD13^+/-, and CD14^+/-; D: R-banded cytogenetic test showed a hyperdiploid karyotype with addition of chromosomes 6, 8, 9, 14, 16, 17, 18 and 22 and t(4;11)(q21;q23) balanced translocation; E: Fluorescence in situ hybridization showed MLL break-apart probe (Y), 1R1G1Y signal and 2R1G1Y atypical signal.