Prognostic significance of sex determining region Y-box 2, E-cadherin, and vimentin in esophageal squamous cell carcinoma

Figure 1 Representative immunochemical staining results of sex determining region Y-box 2, vimentin, and E-cadherin in normal esophagus mucosal tissues (left) and esophageal squamous cell carcinoma tissues (right). A and B: Note that sex determining region Y-box 2 had negative expression in normal esophageal mucosa (A) but positive expression in esophageal squamous cell carcinoma (ESCC) (B); C and D: Vimentin had negative expression in normal esophageal mucosa (C) but positive expression in ESCC (D); E and F: E-cadherin had negative expression in normal esophageal mucosa (E) but positive expression in ESCC cells (F). ESCC: Esophageal squamous cell carcinoma.

Figure 2 Kaplan-Meier curves. A: Kaplan-Meier curves for overall survival of esophageal squamous cell carcinoma patients with sex determining region Y-box 2 positivity vs negativity (P < 0.05); B: Vimentin positivity vs negativity (P < 0.05); C: E-cadherin positivity vs negativity (P = 0.33); D: Different epithelial-mesenchymal transition subtypes (P = 0.029). EMT: Epithelial-mesenchymal transition; SOX2: Sex determining region Y-box 2.