Spinal giant cell-rich osteosarcoma-diagnostic dilemma and treatment strategy: A case report

Figure 1 Preoperative radiographic evaluation. A: Preoperative computed tomography demonstrating collapsed T2 vertebra (yellow arrow); B, C: Preoperative magnetic resonance imaging revealed vertebral body mass (yellow arrow) with paraspinal and epidural paraspinal extension and gadolinium enhancement; D: Bone scan showing an active bone lesion at the upper thoracic spine.

Figure 2 Histopathology of the T2 vertebral tumor. A: Hematoxylin and eosin staining revealing atypical mononuclear oval to plump spindle cells with osteoid formation infiltrating osteoclast-like multinucleated giant cells (arrow); B: Immunohistochemistry demonstrating diffuse H3F3A G34W mutation. Magnification: 400 x.

Figure 3 Postoperative radiographic evaluation. A-C: No tumor recurrence was revealed in the A: 3-mo postoperative computed tomography; B: 4-yr postoperative T2; or C: T1 gadolinium-enhanced magnetic resonance imaging.