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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jul 26, 2022; 10(21): 7565-7570
Published online Jul 26, 2022. doi: 10.12998/wjcc.v10.i21.7565
Published online Jul 26, 2022. doi: 10.12998/wjcc.v10.i21.7565
Spinal giant cell-rich osteosarcoma-diagnostic dilemma and treatment strategy: A case report
Chen-Sheng Tseng, Chia-En Wong, Chi-Chen Huang, Hao-Hsiang Hsu, Jung-Shun Lee, Po-Hsuan Lee, Section of Neurosurgery, Department of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan
Jung-Shun Lee, Department of Cell Biology and Anatomy, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan
Jung-Shun Lee, Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan
Author contributions: Lee PH and Lee JS supervised and coordinated the study; Tseng CS and Lee PH conceived and designed the study; Tseng CS, Wong CE, and Huang CC obtained, analyzed, and interpreted the data; Tseng CS, Wong CE, Lee JS, and Lee PH wrote the manuscript; All authors revised the draft for important intellectual content and agreed upon the manuscript before submission.
Informed consent statement: Informed written consent was obtained from the patient for publication of this reporting
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Po-Hsuan Lee, MD, Surgeon, Section of Neurosurgery, Department of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, No. 138, Shengli Road, North District, Tainan 704, Taiwan.
Received: February 11, 2022
Peer-review started: February 11, 2022
First decision: March 23, 2022
Revised: April 2, 2022
Accepted: May 27, 2022
Article in press: May 27, 2022
Published online: July 26, 2022
Processing time: 149 Days and 23.3 Hours
Peer-review started: February 11, 2022
First decision: March 23, 2022
Revised: April 2, 2022
Accepted: May 27, 2022
Article in press: May 27, 2022
Published online: July 26, 2022
Processing time: 149 Days and 23.3 Hours
Core Tip
Core Tip: Giant cell-rich osteosarcoma (GCRO) is a rare variant of conventional osteosarcoma that is easily misdiagnosed as giant cell tumors. Spinal GCRO poses unique challenges in obtaining a sufficient tissue diagnosis and complete surgical removal. We report a case of spinal GCRO, which was not diagnosed in initial computed tomography-guided biopsy but after T2 corpectomy. Given the relationship between the extent of resection and prognosis, a second salvage operation was performed and gross total resection was achieved. Thus, long-term local control is achievable following complete resection of salvage surgery and adjuvant chemoradiation even in spinal GCRO with previous subtotal resection.