Treatment of gastric hepatoid adenocarcinoma with pembrolizumab and bevacizumab combination chemotherapy: A case report

Figure 1 Imaging examinations performed before treatment. A: Perigastric lymph nodes; B: Liver metastases.

Figure 2 Histological analysis of the patient’s tumour tissue. A: Hematoxylin and eosin staining: tumor cells are arranged in a trabecular patten, with a glandular and hepatoid component (magnification, ×100); B: Hematoxylin and eosin staining: most of them are hepatocyte like differentiation area, and a few are adenocarcinoma area (magnification, ×200); C: Immunohistochemical staining: cells are positively stained for SALL4 (magnification, ×100).

Figure 3 Imaging examinations before and after first-line and second-line treatments. A and C: Curative effect of perigastric lymph nodes: PD; B and D: Curative effect of liver metastases: PD; C and E: Curative effect of perigastric lymph nodes: PR; D and F: Curative effect of liver metastases: PR.

Figure 4 PET- computed tomography examinations at different time after second-line treatment. Persistent remission of perigastric lymph nodes.