Detection of a novel panel of 24 genes with high frequencies of mutation in gastric cancer based on next-generation sequencing

Figure 1 Distribution of the top 16 somatic mutations in the custom panel.

Figure 2 Distribution of the top 16 somatic mutations in the cBioPortal database.

Figure 3 Type and sites of TP53 mutations. A: Distribution of TP53 mutation types in the custom panel; B: Distribution of TP53 mutation types in the cBioPortal database; C: Common mutation sites of TP53.

Figure 4 Type and mutation sites of ERBB2. A: Distribution of ERBB2 mutation types in the custom panel; B: Distribution of ERBB2 mutation types in the cBioPortal database; C: Common mutation sites of ERBB2.

Figure 5 Common mutation sites in the BRCA2, NF1, and PIK3CA genes based on the cBioPortal database. A: BRCA2; B: NF1; C: PIK3CA.

Figure 6 GO and KEGG enrichment analyses of somatically mutated genes. A: GO enrichment analysis; B: KEGG enrichment analysis.

Figure 7 Distribution of microsatellite instability in gastric cancer. A: Distribution of microsatellites in the custom panel; B: Distribution of microsatellites in the cBioPortal database.