PD-1 inhibitor in combination with fruquintinib therapy for initial unresectable colorectal cancer: A case report

Figure 1 The pathology before neoadjuvant therapy. Magnification × 100.

Figure 2 Computed tomography images of the patient (Colon hepatic flexure). A: On the first abdominal computed tomography (CT) examination (2021-05), the intestinal wall at the hepatic curvature of the colon was significantly thickened with enhancement, the surrounding fat space was blurred, and the adjacent lymph nodes were enlarged; B: Abdominal CT examination (2021-07). The range of colonic lesions was reduced, and the surrounding lymph nodes were reduced; C: Abdominal CT examination (2021-09); the results showed improvement compared to the previous imaging results.

Figure 3 Computed tomography images of the patient (para-aortic lymph nodes). A: Abdominal computed tomography (CT) examination (2021-05), enlarged lymph nodes beside the abdominal aorta; B: Abdominal CT examination (2021-07). The para-aortic lymph nodes were smaller than before.

Figure 4 Haematoxylin-eosin staining and immunohistochemistry staining of the colon cancer tissue specimens. Pathology after the neoadjuvant therapy. Magnification × 100.

Figure 5  Abdominal computed tomography examination (2021-11): Postoperative review showed no evidence of recurrence.