Correlation between thrombopoietin and inflammatory factors, platelet indices, and thrombosis in patients with sepsis: A retrospective study

Figure 1 Correlation analyses between thrombopoietin levels and indicators. A: Interleukin (IL)-21 (r = 0.362, P < 0.001); B: IL-6 (r = 0.385, P < 0.001); C: High-sensitivity C-reactive protein (r = 0.531, P < 0.001); D: Platelet count (r = -0.177, P = 0.012); E: Creatinine (r = 0.219, P = 0.002); F: D-dimer (r = 0.453, P < 0.001); G: Prothrombin time (r = 0.311, P < 0.001); H: Fibrinogen (r = 0.438, P < 0.001); I: white blood cells (WBC) (r = 0.176, P = 0.013); J: Hemoglobin concentration (r = -0.209, P = 0.003). TPO: Thrombopoietin; IL-6: Interleukin-6; IL-21: Interleukin-21; hs-CRP: High-sensitivity C-reactive protein; PLT: Platelet count; Cre: Creatinine; DD: D-dimer; PT: Prothrombin time; FIB: Fibrinogen; Hb: Hemoglobin concentration.

Figure 2 Receiver operator characteristic curve analysis for sepsis. Thrombopoietin (TPO) [area under the curve (AUC) = 0.788; 95%CI: 0.723-0.852; P < 0.001]; mean platelet volume (AUC = 0.589; 95%CI: 0.506-0.671; P = 0.036); high-sensitivity C-reactive protein (AUC = 0.947; 95%CI: 0.915-0.979; P < 0.001); interleukin (IL)-6 (AUC = 0.953; 95%CI: 0.922-0.984; P < 0.001); IL-21 (AUC = 0.895; 95%CI: 0.848-0.941; P < 0.001). At a TPO cut-off level of 28.51 pg/mL, the sensitivity was 79%, and specificity was 65%. MPV: Mean platelet volume; TPO: Thrombopoietin; hs-CRP: High-sensitivity C-reactive protein; IL-6: Interleukin-6; IL-21: Interleukin-21.