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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Correlation between thrombopoietin and inflammatory factors, platelet indices, and thrombosis in patients with sepsis: A retrospective study
Wan-Hua Xu, Li-Chan Mo, Mao-Hua Shi, Hui Rao, Xiao-Yong Zhan, Mo Yang
Wan-Hua Xu, Mo Yang, Department of Hematology, Nanfang Hospital/The First School of Clinical Medicine, Southern Medical University, Guangzhou 510515, Guangdong Province, China
Wan-Hua Xu, Li-Chan Mo, Hui Rao, Department of Emergency Medicine, The First People’s Hospital of Foshan, Foshan 528000, Guangdong Province, China
Li-Chan Mo, Department of Emergency Medicine, Nanfang Hospital/The First School of Clinical Medicine, Southern Medical University, Guangzhou 510515, Guangdong Province, China
Mao-Hua Shi, Department of Rheumatology and Immunology, The First People’s Hospital of Foshan, Foshan 528000, Guangdong Province, China
Xiao-Yong Zhan, Mo Yang, Scientific Research Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen 518107, Guangdong Province, China
Mo Yang, Department of Pediatrics, Nanfang Hospital/The First School of Clinical Medicine, Southern Medical University, Guangzhou 510515, Guangdong Province, China
Author contributions: Xu WH contributed to investigation, original draft preparation, funding acquisition, software, and formal analysis; Mo LC and Rao H contributed to software, formal analysis, and resources; Shi MH contributed to methodology and formal analysis; Zhan XY contributed to investigation and data curation; Yang M contributed to conceptualization, manuscript review and editing, and study supervision; all authors have read and agreed to the published version of the manuscript.
Supported by the Guangdong Province Medical Science and Technology Research Foundation, No. B2014377; and the Medical Scientific Research Project of Foshan, No. 20190036.
Institutional review board statement: The study was reviewed and approved by the Medical Ethics Committee of The First People’s Hospital of Foshan, Approval No: L[2021]No. 8.
Informed consent statement: Informed consent to the study is not required due to the retrospective nature of this study.
Conflict-of-interest statement: There are no conflicts of interest to report.
Data sharing statement: Data can be acquired from the corresponding author.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
https://creativecommons.org/Licenses/by-nc/4.0/ Corresponding author: Mo Yang, MD, PhD, Doctor, Department of Hematology, Nanfang Hospital/The First School of Clinical Medicine, Southern Medical University, No. 1023 South Shatai Road, Baiyun District, Guangzhou 510515, Guangdong Province, China.yangm1091@126.com
Received: November 3, 2021
Peer-review started: November 3, 2021
First decision: December 27, 2021
Revised: January 24, 2022
Accepted: March 15, 2022
Article in press: March 15, 2022
Published online: May 6, 2022
Processing time: 177 Days and 16.5 Hours
ARTICLE HIGHLIGHTS
Research background
Elevated levels of thrombopoietin (TPO) are often accompanied by a decrease in platelet count (PLT) in systemic infectious conditions, contrary to the view that TPO promotes platelet production under physiological conditions. In addition, whether TPO mediates organ damage in sepsis remains controversial.
Research motivation
The role of TPO in sepsis is not well determined. It is necessary to understand the role of TPO in the pathophysiological process of sepsis and the relationship between TPO and other inflammatory factors, platelet indices, and thrombotic indicators.
Research objectives
To explore the relationships between TPO and inflammatory factors, platelet indices, and thrombotic indicators in sepsis.
Research methods
Patients with sepsis diagnosed and treated at the Emergency Medicine Department were enrolled in this study. Patients without sepsis were included as controls. Clinical and laboratory parameters were collected. Pearson’s and Spearman’s correlation analyses were used for bivariable analyses of data with a normal- and non-normal distribution, respectively. Logistic regression models were used for univariable and multivariable regression to analyze the risk factors of sepsis. Receiver operator characteristic analysis was executed to evaluate the discriminative ability of the monograph.
Research results
TPO levels were higher in the sepsis group than in controls, but platelets were lower. TPO was an independent risk factor associated with sepsis. TPO levels were positively correlated with inflammatory factors and some thrombotic indicators, and negatively correlated with PLT. TPO had fair predictive value in distinguishing septic patients and non-septic patients.
Research conclusions
TPO levels are independently associated with sepsis. TPO might be an acute-phase response protein in patients with infection.
Research perspectives
Future studies will further investigate whether TPO has prognostic value in sepsis.
