Combination therapy (toripalimab and lenvatinib)-associated toxic epidermal necrolysis in a patient with metastatic liver cancer: A case report

Figure 1 Clinical images before and after treatment. A: Erythema, blisters and erosions appeared on the face and neck, as well as the oral mucosa; B: Typical erythema multiforme, slack bullae and epidermal peeling could be seen and covered more than 70% of the body surface area; C and D: The rashes gradually faded after 3 wk of treatment.

Figure 2 Pathological biopsy of the lesion. A: Acantholytic bullae were observed in the epidermis [hematoxylin-eosin staining (HE) × 40]; B: Hyperkeratosis and liquefaction of basal cells could be seen in the epidermis. Blood vessels in the dermis were infiltrated by lymphocytes and eosinophils (HE × 100); C: Prominent necrotic keratinocytes were identified in the epidermis (HE × 400).