Retrospective Study
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Mar 6, 2021; 9(7): 1600-1609
Published online Mar 6, 2021. doi: 10.12998/wjcc.v9.i7.1600
Study on pathogenic genes of dwarfism disease by next-generation sequencing
Lv-Lv Yang, Shi-Shan Liang
Lv-Lv Yang, Shi-Shan Liang, Department of Pediatrics, Quanzhou First Hospital, Quanzhou 362000, Fujian Province, China
Author contributions: Yang LL designed the study and performed the research; Liang SS analyzed the data; Yang LL wrote the paper and revised the manuscript for final submission.
Supported by Quanzhou Science and Technology Bureau, No. 2018Z072
Institutional review board statement: The study was reviewed and approved by the Quanzhou First Hospital Review Board.
Informed consent statement: All study participants or their legal guardian provided written informed consent prior to study enrollment.
Conflict-of-interest statement: We declare that we have no financial or personal relationships with other individuals or organizations that can inappropriately influence our work and that there is no professional or other personal interest of any nature in any product, service and/or company that could be construed as influencing the position presented in or the review of the manuscript.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Lv-Lv Yang, MD, Doctor, Department of Pediatrics, Quanzhou First Hospital, No. 248-252 East Street, Licheng District, Quanzhou 362000, Fujian Province, China. lvlv8000@126.com
Received: November 23, 2020
Peer-review started: November 23, 2020
First decision: December 8, 2020
Revised: December 10, 2020
Accepted: December 24, 2020
Article in press: December 24, 2020
Published online: March 6, 2021
Processing time: 97 Days and 16.4 Hours
Core Tip

Core Tip: Genetic variation may relate to the incidence of dwarfism. After Solexa sequencing, the OBSL1, SLC26A2, PTPN11, COL27AI, HDAC6, CUL7, FGFR3, DYNC2H1, GH1, and ATP7B genes may be related to dwarfism and clarify the molecular cause.