Retrospective Study
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Mar 6, 2021; 9(7): 1580-1591
Published online Mar 6, 2021. doi: 10.12998/wjcc.v9.i7.1580
Short-term outcomes of radiofrequency ablation for hepatocellular carcinoma using cone-beam computed tomography for planning and image guidance
Xue-Song Yao, Dong Yan, Xian-Xian Jiang, Xiao Li, Hui-Ying Zeng, Huai Li
Xue-Song Yao, Dong Yan, Xiao Li, Hui-Ying Zeng, Huai Li, Department of Interventional Therapy, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
Xian-Xian Jiang, Australian Research Council Training Centre for Innovation in Biomedical Imaging Technology, University of Queensland, Brisbane 4000, Australia
Author contributions: Li H and Yao XS contributed to study concept and design; Yan D and Zeng HY contributed to performing the RFA procedure; Yao XS and Jiang XX contributed to acquisition of clinical data, statistical analysis, and data interpretation; Yao XS wrote the first draft of the manuscript; Li X wrote sections of the manuscript; Li H and Li X supervised and oversaw the study.
Institutional review board statement: The study was reviewed and approved by the [Ethics Committee of Cancer Institute and Hospital, Chinese Academy of Medical Sciences] Institutional Review Board (No. 14-049/839).
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors declare no conflicts of interest related to this manuscript.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Huai Li, MD, Chief Doctor, Department of Interventional Therapy, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17 Panjiayuan Nanli, Chaoyang District, Beijing 100021, China. lihuai1956@hotmail.com
Received: September 20, 2020
Peer-review started: September 20, 2020
First decision: December 4, 2020
Revised: December 22, 2020
Accepted: January 8, 2021
Article in press: January 8, 2021
Published online: March 6, 2021
Processing time: 162 Days and 2.5 Hours
Core Tip

Core Tip: This is a prospective study to assess the treatment response to radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) using cone-beam computed tomography (CBCT) for treatment planning and image guidance. Satisfactory 1-, 2-, and 3-year overall survival and disease progression outcomes were achieved in patients with solitary HCC when treated by RFA under CBCT. Image fusion of pre-operative CT/magnetic resonance imaging with CBCT allows precise RFA treatment planning and real-time image guidance. The initial treatment response strongly correlates with RFA planning and is an independent predictor of short-term outcomes, implying the necessity of reliable treatment planning.