Case Report
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Feb 26, 2021; 9(6): 1475-1482
Published online Feb 26, 2021. doi: 10.12998/wjcc.v9.i6.1475
Congenital hepatic fibrosis in a young boy with congenital hypothyroidism: A case report
Fang-Fei Xiao, Yi-Zhong Wang, Fang Dong, Xiao-Lu Li, Ting Zhang
Fang-Fei Xiao, Yi-Zhong Wang, Fang Dong, Xiao-Lu Li, Ting Zhang, Department of Gastroenterology, Hepatology and Nutrition, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai 200062, China
Author contributions: Xiao FF and Zhang T designed the study; Xiao FF and Wang YZ drafted the manuscript; Dong F and Li XL collected data and pictures; Wang YZ and Zhang T edited the manuscript; all authors agreed to be accountable for all aspects of the work; all authors have read and approved the final manuscript.
Supported by National Natural Science Foundation of China, No. 81870373; Shanghai Hospital Development Center New Frontier Technology Joint Research Project, No. SHDC12017115; and 2019 Shanghai “Innovative Action Plan of Science and Technology” Animal Research Project Guide, No. 19140904301.
Informed consent statement: Written informed consents were obtained from the parents of the patient for the publication of this study.
Conflict-of-interest statement: The authors declare that they have no competing interests.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ting Zhang, MD, PhD, Professor, Department of Gastroenterology, Hepatology and Nutrition, Shanghai Children's Hospital, Shanghai Jiao Tong University, No. 355 Luding Road, Shanghai 200062, China. zhangt@shchildren.com.cn
Received: November 4, 2020
Peer-review started: November 4, 2020
First decision: November 20, 2020
Revised: November 27, 2020
Accepted: December 16, 2020
Article in press: December 16, 2020
Published online: February 26, 2021
Core Tip

Core Tip: Congenital hepatic fibrosis (CHF) is often accompanied by a variety of diseases, but this case introduces a rare comorbidity of CHF and congenital hypothyroidism (CH). Moreover, this report includes a detailed process of its diagnosis and treatment, which highlights that timely liver biopsy and genetic testing can be valuable tools for the diagnosis and differential diagnosis of CH coexistent with unexplained abnormal liver function.