Clinical Trials Study
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Feb 26, 2021; 9(6): 1293-1303
Published online Feb 26, 2021. doi: 10.12998/wjcc.v9.i6.1293
Etomidate vs propofol in coronary heart disease patients undergoing major noncardiac surgery: A randomized clinical trial
Zhong-Liang Dai, Xing-Tao Cai, Wen-Li Gao, Miao Lin, Juan Lin, Yuan-Xu Jiang, Xin Jiang
Zhong-Liang Dai, Xing-Tao Cai, Wen-Li Gao, Miao Lin, Juan Lin, Yuan-Xu Jiang, Department of Anesthesiology, The First Affiliated Hospital of Southern University, The Second Clinical Medical College of Jinan University, Shenzhen People’s Hospital, Shenzhen 518020, Guangdong Province, China
Xin Jiang, Department of Geriatrics, The First Affiliated Hospital of Southern University, The Second Clinical Medical College of Jinan University, Shenzhen People’s Hospital, Shenzhen 518020, Guangdong Province, China
Author contributions: Dai ZL, Jiang YX, and Jiang X designed the study and analyzed the data; Cai XT, Gao WL and Lin M collected the data; Dai ZL, Lin J, and Cai XT interpreted the data; Dai ZL, Jiang YX, and Jiang X prepared the manuscript; all authors have read and approved the manuscript.
Supported by Shenzhen Municipal Science and Technology Foundation, No. JCYJ20170307100314152; Shenzhen Health Research Fund, No. SZLY2018011 and No. SZXJ2017029; Guangdong Medical Research Fund, No. A2018008 and No. A2019382; Scientific Research Fund of Shenzhen People’s Hospital, No. SYLY201706; and Shenzhen Key Medical Discipline Construction Fund, No. SZXK012.
Institutional review board statement: The study was approved by the Ethics Committee of Shenzhen People’s Hospital (No. LL-KT-2014211) and conducted according to the Declaration of Helsinki.
Clinical trial registration statement: The trial was registered in Chinese Clinical Trial Registry on August 15, 2019 (ChiCTR1900025174) and is available at http://www.chictr.org.cn/showproj.aspx?proj=42063.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CONSORT 2010 statement: The authors have read the CONSORT 2010 Statement, and the manuscript was prepared and revised according to the CONSORT 2010 Statement.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xin Jiang, MD, Doctor, Department of Geriatrics, the First Affiliated Hospital of Southern University, the Second Clinical Medical College of Jinan University, Shenzhen People’s Hospital, No. 1017 Dongmen North Road, Luohu District, Shenzhen 518020, Guangdong Province, China. jiangxinsz@163.com
Received: November 10, 2020
Peer-review started: November 10, 2020
First decision: December 8, 2020
Revised: December 17, 2020
Accepted: December 27, 2020
Article in press: December 27, 2020
Published online: February 26, 2021
Processing time: 87 Days and 20.7 Hours
Core Tip

Core Tip: The results show that in patients with coronary heart disease undergoing noncardiac major surgery, etomidate-based anesthesia was associated with fewer cardiovascular events and smaller hemodynamic changes than propofol-based anesthesia.