Case Report
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Feb 16, 2021; 9(5): 1119-1126
Published online Feb 16, 2021. doi: 10.12998/wjcc.v9.i5.1119
Primary aldosteronism due to bilateral micronodular hyperplasia and concomitant subclinical Cushing’s syndrome: A case report
Hiroki Teragawa, Chikage Oshita, Yuichi Orita, Kunihiro Hashimoto, Hirofumi Nakayama, Yuto Yamazaki, Hironobu Sasano
Hiroki Teragawa, Chikage Oshita, Yuichi Orita, Department of Cardiovascular Medicine, JR Hiroshima Hospital, Hiroshima 732-0057, Japan
Kunihiro Hashimoto, Department of Urology, JR Hiroshima Hospital, Hiroshima 732-0057, Japan
Hirofumi Nakayama, Department of Pathology and Laboratory Medicine, JR Hiroshima Hospital, Hiroshima 732-0057, Japan
Yuto Yamazaki, Hironobu Sasano, Department of Pathology, Tohoku University Graduate School of Medicine, Sendai 980-8574, Japan
Author contributions: Teragawa H, Oshita C and Orita Y performed some endocrinologic and imaging examinations, reviewed the literature and contributed to manuscript drafting; Hashimoto K was the patient’s urological surgeon and contributed to manuscript drafting; Nakayama H performed the histopathological analyses and interpretation and contributed to manuscript drafting; Yamazaki Y and Sasano H performed the histopathological and immunohistochemical analyses and interpretation and contributed to manuscript drafting; all authors issued final approval for the version to be submitted.
Informed consent statement: Informed written consent was obtained from the patient for the surgical procedure, the publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hiroki Teragawa, FACC, FACP, FAHA, MD, PhD, Chief Doctor, Department of Cardiovascular Medicine, JR Hiroshima Hospital, 3-1-36 Futabanosato, Higashi-ku, Hiroshima 732-0057, Japan. hiroki-teragawa@jrhh.or.jp
Received: September 10, 2020
Peer-review started: September 10, 2020
First decision: November 23, 2020
Revised: December 3, 2020
Accepted: January 7, 2021
Article in press: January 7, 2021
Published online: February 16, 2021
Processing time: 142 Days and 3.8 Hours
Core Tip

Core Tip: Adrenal incidentaloma (AI) has been frequently encountered in the clinical setting. It has been shown that primary aldosteronism (PA) or subclinical Cushing’s syndrome (SCS) are the representative causative diseases of AI. However, the coexistence of PA and SCS has been reportedly observed. In the present case report, we describe a case of AI, in which PA and SCS coexisted after endocrinologic examinations, which was ultimately confirmed by histopathological examinations after a laparoscopic adrenalectomy. Careful clinical examinations should be performed when patients harboring AI present with concomitant SCS and PA.