Case Report
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Feb 16, 2021; 9(5): 1103-1110
Published online Feb 16, 2021. doi: 10.12998/wjcc.v9.i5.1103
Treatment of pediatric intracranial dissecting aneurysm with clipping and angioplasty, and next-generation sequencing analysis: A case report and literature review
Ning Sun, Xin-Yu Yang, Yan Zhao, Qing-Jiang Zhang, Xiao Ma, Zhong-Nan Wei, Meng-Qi Li
Ning Sun, Qing-Jiang Zhang, Xiao Ma, Zhong-Nan Wei, Department of Neurosurgery, Tianjin Children's Hospital/Tianjin University Children's Hospital, Tianjin 300134, China
Xin-Yu Yang, Yan Zhao, Meng-Qi Li, Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin 300052, China
Author contributions: Sun N, Yang XY, and Zhao Y drafted the manuscript; Zhang QJ and Ma X prepared the figures; Wei ZN and Li MQ prepared the clinical and imaging data; Sun N finalized the manuscript; Yang XY checked and reviewed the article; All authors read and approved the final draft.
Supported by National Natural Science Foundation of China, No. 81571144
Informed consent statement: Informed written consent was obtained from the parents of the patient for publication of this report and accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016)
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ning Sun, MD, Surgeon, Department of Neurosurgery, Tianjin Children's Hospital/Tianjin University Children's Hospital, No. 238 Longyan Road, Beichen District, Tianjin 300134, China. sunning64tj@yahoo.com
Received: August 12, 2020
Peer-review started: August 12, 2020
First decision: December 3, 2020
Revised: December 11, 2020
Accepted: December 23, 2020
Article in press: December 23, 2020
Published online: February 16, 2021
Core Tip

Core Tip: The index case was a 3-year-old boy with a large ruptured intracranial dissecting aneurysm in the right middle cerebral artery (16 mm × 14 mm). He was successfully treated by clipping and angioplasty. Whole-genome high-throughput sequencing identified the rs78977446 variant of the ADAMTS13 gene. Bioinformatics analysis using the American College of Medical Genetics guidelines and literature search suggested that this variant is a risk factor for pediatric intracranial dissecting aneurysm.