Systematic Reviews
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Feb 16, 2021; 9(5): 1058-1078
Published online Feb 16, 2021. doi: 10.12998/wjcc.v9.i5.1058
Clinical features of SARS-CoV-2-associated encephalitis and meningitis amid COVID-19 pandemic
Liang Huo, Kai-Li Xu, Hua Wang
Liang Huo, Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China
Kai-Li Xu, Department of Pediatric Neurology, Children’s Hospital Affiliated to Zhengzhou University, Zhengzhou 450018, Henan Province, China
Kai-Li Xu, Department of Pediatric Neurology, Henan Children’s Hospital, Zhengzhou 450018, Henan Province, China
Hua Wang, Department of Pediatric Neurology, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China
Author contributions: Huo L designed the study, analyzed the data, and drafted the paper; Xu KL analyzed the data and drafted the paper; Wang H collected the data; all authors read and approved the final manuscript.
Supported by Liaoning Provincial Department of Education Scientific Research Project, No. QNZR2020012; Henan Neural Development Engineering Research Center for Children Foundation, No. SG201905; and the National Key Research and Development Program of China, No. 2016YFC1306203.
Conflict-of-interest statement: All the authors declare that they have no conflicts of interest to report.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Liang Huo, MD, PhD, Associated Professor, Department of Pediatrics, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Heping District, Shenyang 110004, Liaoning Province, China. huol@sj-hospital.org
Received: November 5, 2020
Peer-review started: November 5, 2020
First decision: November 23, 2020
Revised: December 1, 2020
Accepted: December 23, 2020
Article in press: December 23, 2020
Published online: February 16, 2021
Processing time: 86 Days and 5.6 Hours
Core Tip

Core Tip: Since the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic, although many cases or cases series of SARS-CoV-2-related encepha-litis/meningitis have been reported, the specific clinical characteristics of SARS-CoV-2-relatedencephalitis/meningitis have not been systematically described. We retrospectively analyzed and summarized the comprehensive clinical characteristics of SARS-CoV-2-related encephalitis/meningitis, including demographic characteristics, diagnostic investigations, and outcomes.