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©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Feb 16, 2021; 9(5): 1016-1025
Published online Feb 16, 2021. doi: 10.12998/wjcc.v9.i5.1016
Published online Feb 16, 2021. doi: 10.12998/wjcc.v9.i5.1016
Serum neuron-specific enolase: A promising biomarker of silicosis
Hong-Bo Huang, Jun-Ling Huang, Xiao-Ting Xu, Yi-Jian Lin, Xi-Bin Zhuang, Department of Pulmonary and Critical Care Medicine, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou 362000, Fujian Province, China
Kun-Bo Huang, Department of Clinical Laboratory, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou 362000, Fujian Province, China
Jie-Bin Lin, Department of Internal Medicine, Infectious Disease Hospital of Quanzhou, Quanzhou 362000, Fujian Province, China
Author contributions: Huang HB, Huang JL, Xu XT, Huang KB, Lin YJ, and Lin JB performed the experiments and wrote the manuscript; Zhuang XB designed the study and corrected the manuscript.
Supported by Quanzhou Science and Technology Bureau , No. 2018N053S .
Institutional review board statement: The study was approved by the Ethics Committee of Quanzhou First Hospital affiliated to Fujian Medical University.
Informed consent statement: All participants gave signed informed consent.
Conflict-of-interest statement: All the authors declare that there is no conflict of interest.
Data sharing statement: No additional data.
STROBE statement: The manuscript was revised according to the STROBE Statement.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jun-Ling Huang, MD, Attending Doctor, Department of Pulmonary and Critical Care Medicine, Quanzhou First Hospital Affiliated to Fujian Medical University, No. 248-252 East Street, Quanzhou 362000, Fujian Province, China. 236992065@qq.com
Received: November 10, 2020
Peer-review started: November 10, 2020
First decision: November 29, 2020
Revised: December 12, 2020
Accepted: December 23, 2020
Article in press: December 23, 2020
Published online: February 16, 2021
Peer-review started: November 10, 2020
First decision: November 29, 2020
Revised: December 12, 2020
Accepted: December 23, 2020
Article in press: December 23, 2020
Published online: February 16, 2021
Core Tip
Core Tip: The purpose of this study was to investigate the clinical significance of serum neuron-specific enolase (NSE) in the diagnosis and staging of silicosis. The results showed that the serum NSE concentration of silicosis patients was significantly higher than that of non-silicosis patients. With the progression of silicosis, NSE concentration increased gradually. The receiver operating characteristic curve suggested that when the diagnostic threshold of NSE was 15.82 ng/mL, the area under the curve was 0.858 (P = 0.000), with sensitivity of 72% and specificity of 90%. To the best of our knowledge, this study is the largest study on silicosis biomarkers to date.