Case Report
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Feb 6, 2021; 9(4): 878-885
Published online Feb 6, 2021. doi: 10.12998/wjcc.v9.i4.878
Clinical characteristics and ABCC2 genotype in Dubin-Johnson syndrome: A case report and review of the literature
Huan Wu, Xue-Ke Zhao, Juan-Juan Zhu
Huan Wu, Xue-Ke Zhao, Juan-Juan Zhu, Department of Infectious Diseases, The Affiliated Hospital of Guizhou Medical University, Guiyang 550001, Guizhou Province, China
Author contributions: Zhu JJ contributed to conceptualization and funding acquisition; Wu H, Zhu JJ and Zhao XK contributed to analyzing and interpreting the patient data, and performing the experiments; Wu H and Zhao XK contributed to paper writing and revision; All authors read and approved the final manuscript.
Supported by The Talents of Qiankehe platform of China, No. [2018]5779-40; the Zhuke Contract, No. [2018]1-92; and the Qiankehe Support, No. [2017]2874.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: We declare that we have no conflicts of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Juan-Juan Zhu, MD, Assistant Professor, Department of Infectious Diseases, The Affiliated Hospital of Guizhou Medical University, No. 28 Guiyi Street, Guiyang 550001, Guizhou Province, China. 184184239@qq.com
Received: September 1, 2020
Peer-review started: September 1, 2020
First decision: November 8, 2020
Revised: November 20, 2020
Accepted: December 6, 2020
Article in press: December 6, 2020
Published online: February 6, 2021
Processing time: 146 Days and 2.3 Hours
Core Tip

Core Tip: Our study reported the pathological characteristics and a new ABCC2 mutation in a patient with Dubin-Johnson syndrome (DJS). A 24-year-old female with intermittent jaundice and conjugated hyperbilirubinemia underwent laparoscopic exploration and liver biopsy, which confirmed the diagnosis of DJS. Next-generation sequencing analysis showed ABCC2 mutations. Our study reports a novel ABCC2 mutation in a DJS patient.