Hayashi K, Yamamoto N, Takeuchi A, Miwa S, Igarashi K, Araki Y, Yonezawa H, Morinaga S, Asano Y, Tsuchiya H. Long-term survival in a patient with Hutchinson-Gilford progeria syndrome and osteosarcoma: A case report. World J Clin Cases 2021; 9(4): 854-863 [PMID: 33585632 DOI: 10.12998/wjcc.v9.i4.854]
Corresponding Author of This Article
Katsuhiro Hayashi, MD, PhD, Professor, Department of Orthopaedic Surgery, Kanazawa University, Takaramachi 13-1, Kanazawa 9208641, Japan. khayashi830@gmail.com
Research Domain of This Article
Orthopedics
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Katsuhiro Hayashi, Norio Yamamoto, Akihiko Takeuchi, Shinji Miwa, Kentaro Igarashi, Yoshihiro Araki, Hirotaka Yonezawa, Sei Morinaga, Yohei Asano, Hiroyuki Tsuchiya, Department of Orthopaedic Surgery, Kanazawa University, Kanazawa 9208641, Japan
Author contributions: Hayashi K, Yamamoto N and Tsuchiya H were the patient’s surgeons, reviewed the literature and contributed to manuscript drafting; Takeuchi A, Miwa S and Igarashi K reviewed the literature and contributed to manuscript drafting; Araki Y analyzed and interpreted the imaging findings; Yonezawa H, Morinaga S and Asano Y were responsible for the revision of the manuscript for important intellectual content; all authors issued final approval for the version to be submitted.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Katsuhiro Hayashi, MD, PhD, Professor, Department of Orthopaedic Surgery, Kanazawa University, Takaramachi 13-1, Kanazawa 9208641, Japan. khayashi830@gmail.com
Received: August 4, 2020 Peer-review started: August 4, 2020 First decision: November 3, 2020 Revised: December 3, 2020 Accepted: December 23, 2020 Article in press: December 23, 2020 Published online: February 6, 2021 Processing time: 173 Days and 22 Hours
Core Tip
Core Tip: We report the first case describing the detailed surgical procedure and long-term follow-up of osteosarcoma in a patient with Hutchinson-Gilford progeria syndrome (HGPS). This patient had symptoms of HGPS at birth and was diagnosed at 5 years of age. After the diagnosis of osteosarcoma in proximal tibia, a pedicle frozen autograft using liquid nitrogen was performed to cure her osteosarcoma, and limb salvage was achieved 13 years post-operatively. The patient had a number of surgical site complications, such as wound dehiscence, and superficial and deep infections due to vulnerable skin in HGPS. If the megaprosthesis was chosen, infection could not be subsided and an amputation would eventually be done. Even though amputation was selected, a prosthetic leg would not be applicable because of the poor condition of the skin. Cardiovascular disorders did not develop until 24 years of age and thyroid cancer has been successfully managed by surgery and levothyroxine for 13 years. Due to the morphologic characteristics of bone, vulnerable skin condition, and decreased subcutaneous tissue, the treatment strategy for osteosarcoma in HGPS is complicated. A biological reconstruction method is recommended to manage post-operative complications.