Case Report
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Dec 26, 2021; 9(36): 11457-11466
Published online Dec 26, 2021. doi: 10.12998/wjcc.v9.i36.11457
Severe digital ischemia coexists with thrombocytopenia in malignancy-associated antiphospholipid syndrome: A case report and review of literature
Jia-Lei Chen, Xi Yu, Rong Luo, Ming Liu
Jia-Lei Chen, Rong Luo, Ming Liu, Department of Orthopedics, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Xi Yu, Department of Rehabilitation, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Author contributions: Chen JL was the patient’s physicians and contributed to manuscript drafting; Yu X was the patient’s physical therapist and helped with acquisition of the data. Chen JL and Luo R reviewed the literature and interpreted the imaging findings; Liu M and Chen JL were responsible for the revision of the manuscript for important intellectual content; all authors have read and approved the final manuscript.
Informed consent statement: Informed written consent was obtained from the patient and the patient's daughter as a legally authorized representative for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jia-Lei Chen, MD, PhD, Attending Doctor, Department of Orthopedics, West China Hospital, Sichuan University, No. 37 Guoxue Alley, Wuhou District, Chengdu 610041, Sichuan Province, China. chenjialei2016@wchscu.cn
Received: July 22, 2021
Peer-review started: July 22, 2021
First decision: September 2, 2021
Revised: September 8, 2021
Accepted: November 18, 2021
Article in press: November 18, 2021
Published online: December 26, 2021
Core Tip

Core Tip: Paraneoplastic syndromes, compared with cancer, are characterized by atypical clinical manifestations. This report described a case of hepatocellular carcinoma in which the presenting symptom was severe digital ischemia, mimicking Raynaud’s phenomenon, accompanied with thrombocytopenia, associated with antiphospholipid antibodies. This report highlights the importance of atypical clinical changes that could alert the physicians to be vigilant for concomitant underlying malignancy.