Meta-Analysis
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Dec 16, 2021; 9(35): 10969-10978
Published online Dec 16, 2021. doi: 10.12998/wjcc.v9.i35.10969
Clinical significance of signet ring cells in surgical esophageal and esophagogastric junction adenocarcinoma: A systematic review and meta-analysis
Yi-Fan Wang, Si-Yu Xu, Yan Wang, Guo-Wei Che, Hai-Tao Ma
Yi-Fan Wang, Department of Thoracic Surgery, Affiliated Hospital of Chengdu University, Chengdu 610081, Sichuan Province, China
Yi-Fan Wang, Hai-Tao Ma, Department of Thoracic Surgery, The First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu Province, China
Si-Yu Xu, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Yan Wang, Guo-Wei Che, Department of Thoracic Surgery, West China Hospital, Chengdu 610041, Sichuan Province, China
Author contributions: Ma HT made substantial contributions to the conception and design of the work; Wang YF and Xu SY searched and selected the materials and extracted the data; Wang YF and Xu SY wrote this manuscript; Yan Wang and Che GW revised the paper carefully and also contributed to the statistical analysis; Wang YF and Xu SY contributed equally to this work; and all authors have read and approved the final manuscript.
Conflict-of-interest statement: The authors declare no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
PRISMA 2009 Checklist statement: This systematic review and meta-analysis were conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hai-Tao Ma, MD, Professor, Department of Thoracic Surgery, The First Affiliated Hospital of Soochow University, No. 899 Pinghai Road, Suzhou 215006, Jiangsu Province, China. mht7403@163.com
Received: June 18, 2021
Peer-review started: June 18, 2021
First decision: July 26, 2021
Revised: July 29, 2021
Accepted: October 25, 2021
Article in press: October 25, 2021
Published online: December 16, 2021
Processing time: 175 Days and 4.4 Hours
Core Tip

Core Tip: Our manuscript indicated that the presence of signet ring cells (SRCs) was significantly associated with the tumor location (P = 0.022) and tumor-node-metastasis stage (P = 0.031). Meanwhile, the presence of SRCs in surgical esophageal and esophagogastric junction adenocarcinoma (EEGJA) patients predicted a poor overall survival (P = 0.002) and disease-specific survival (P < 0.001). The presence of SRC was related with advanced tumor stage and poor prognosis and could serve as a reliable and effective parameter for the prediction of postoperative survival and formulation of therapy strategy in EEGJA patients. However, more high-quality studies are still needed to verify the above findings.